Methanesulfonyl chloride → 4-Methanesulfonamidophthalimide

HRID 478609노트

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HRID 478609 반응식
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 729154-Aminophthalimide

생성물 1

HCID 9750204-Methanesulfonamidophthalimide수율 76.1%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Methanesulfonylchloride (2.6 ml, 0.034 mol) was added dropwise to a stirred suspension of 4-aminophthalimide (5.0 g, 0.031 mol) in pyridine (50 ml). The mixture was stirred for 48 h under N2 at room temperature, after which time the solid formed was isolated by filtration, washing well with H2O and CH2Cl2 and then dried in vacuo to afford the subtitle compound as a colourless solid (5.67 g, 76%). Rf 0.52 (CH2Cl2/MeOH/0.88NH3 90/10/1, v/v). MS m/z 241 (MH+).

후처리

  1. customafter which time the solid formed
  2. customwas isolated by filtration
  3. washwashing well with H2O and CH2Cl2
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-933d715db37142eba0f3628796134310
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642242B2

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