Pyridine → HCID 11608128, 화합물

HRID 478639노트

반응식

HRID 478639 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:19](=[O:21])[CH3:20])[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 698734-Phenylpiperidine

생성물 1

HCID 11608128HCID 11608128, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

4-Phenylpiperidine (87 mmol) and pyridine (96 mmol) are dissolved in dry CH2Cl2 (100 ml) and acetylchloride (96 mmol) in CH2Cl2 (40 ml) is added dropwise to the stirred solution at 10° C. The reaction is stirred for 1 hour at rt. The mixture is extracted three times with water and the water phase is extracted again with CH2Cl2. The combined organic phases are dried over sodium sulfate and evaporated. A pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained.

후처리

  1. extractionThe mixture is extracted three times with water
  2. extractionthe water phase is extracted again with CH2Cl2
  3. dry with materialThe combined organic phases are dried over sodium sulfate
  4. customevaporated
  5. customA pale brown oil with Rf=0.13 (ethyl acetate/hexane=1:1) is obtained

출처 및 근거

ORD 기록
ord-ca110666b0384f00a99ffea359f5cb59
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642239B2

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