참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3-Methyl-indan-1-one | HCID 259560 | — |
| 반응물 | Oxindole | HCID 321710 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(3-Methylindan-1-ylidene)-1,3-dihydroindol-2-one | HCID 57034405 | 13.4% |
반응 단계
A mixture of 0.5 g of 3-methyl-1-indanone, 1.37 g oxindole and 5 ml piperidine in 3 ml of dimethylforamide was heated in a sealed tube at 130° C. overnight to yield a reddish-brown suspension. The mixture was added to 1N hydrochloric acid solution and extracted with ethyl acetate. The organic layer was washed with brine, dried with magnesium sulfate and concentrated. Chromatography afforded 120 mg of 3-(3-methylindan-1-ylidene)-1,3-dihydroindol-2-one as an orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06642251B1 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-93565151183748cd92aef058f334cf1e |
|---|
| 출처 메모 | uspto-grants-2003_11 |
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