5-(1,3-Benzothiazol-2-yl)pentanoic acid → Methyl 5-(1,3-benzothiazol-2-yl)pentanoate

HRID 478738노트

반응식

HRID 478738 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15].Cl.[CH3:18]O>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH3:18])=[O:15]

참가 물질

3

반응물 2

HCID 19714935-(1,3-Benzothiazol-2-yl)pentanoic acidHCID 21893726Hydrochloride methanol

생성물 1

HCID 18002644Methyl 5-(1,3-benzothiazol-2-yl)pentanoate수율 67%

실험 절차

A solution of 5-(2-benzothiazolyl)pentanoic acid (1.54 g, 6.5 mmol, prepared according to the procedure of Example 12 in JP, A, 8-208631 (1996)) in hydrochloric acid-methanol (40 ml) was stirred at room temperature overnight, and evaporated. The residue was dissolved in chloroform, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulfate, evaporated, and purified through flash column chromatography to give methyl 5-(2-benzothiazolyl)pentanoate (1.08 g, 67%).

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customevaporated
  6. custompurified through flash column chromatography

출처 및 근거

ORD 기록
ord-6ea897a685174315ac633287610bf07e
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642250B2

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