Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → cis-Dimethyl 1-benzylpyrrolidine-3,4-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-(Benzylamino)acetic acid | HCID 86965 | — |
| 반응물 | Dimethyl maleate | HCID 5271565 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | cis-Dimethyl 1-benzylpyrrolidine-3,4-dicarboxylate | HCID 10978757 | 34.6% |
반응 단계
A solution of N-benzylglycine (12.39 g, 75 mmol), dimethyl maleate (6.26 g, 50 mmol), paraformaldehyde (4.5 g, 150 mmol) and DIEA (8.7 mL, 50 mmol) in toluene (100 mL) was stirred at reflux for 2 hours and concentrated. The residue was taken up in EtOAc. The solution was washed with brine 3×, dried (MgSO4) and concentrated. Column chromatography eluting with 50% EtOAc/hexanes provided dimethyl cis-1-benzyl-3,4-pyrrolidinedicarboxylate (4.8 g, 34%). MS (M+H)+=278.5.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642255B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-46dd9d23806947f28dc42014a3fe4a85 |
| 출처 메모 | uspto-grants-2003_11 |