2,5-Difluorophenylacetic acid → N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

HRID 478823노트

반응식

HRID 478823 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH2:20])[CH:14]([CH3:16])[CH3:15]>>[CH2:13]([O:17][C:18](=[O:22])[C@H:19]([CH3:21])[NH:20][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[F:1])[CH:14]([CH3:16])[CH3:15]

참가 물질

3

반응물 2

HCID 5228232,5-Difluorophenylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

생성물 1

HCID 22894969N-[(2,5-difluorophenyl)acetyl]aIanine iso-butyl ester

실험 절차

Following General Procedure I above, and using 2,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

후처리

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

출처 및 근거

ORD 기록
ord-35d1ad9dc9fd450b8df299aa376c7cf6
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642261B2

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