Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-2-thiopseudourea → neomycin B gamma-guanidino butyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-2-thiopseudourea | HCID 5142 | — |
| 반응물 | O-Methylisourea | HCID 75544 | — |
| 반응물 | neomycin B gamma-amino butyric acid | HCID 131724201 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | neomycin B gamma-guanidino butyric acid | HCID 178512978 | — |
반응 단계
For guanylation, the neomycin B/γ-amino butyric acid conjugate obtained in Example 9a above is treated with O-methyl isourea or S-methyl isothiourea in water at basic pH for 34 days, resulting in guanylation of the terminal amino groups. The product is purified by ion exchange chromatography, yielding the neomycin B/γ-guanidino butyric acid conjugate 17.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642365B1 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-c6f4edae96e8479896f6d399ccd53340 |
| 출처 메모 | uspto-grants-2003_11 |