참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 2-Cyano-4-methylpent-2-enoic acid | HCID 292547 | — |
| 반응물 | HCID 178455855 | HCID 178455855 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Cyano-3-isopropyl-hexanoic acid methyl ester | HCID 54152185 | — |
반응 단계
A 2.0 M solution of propyl magnesium chloride in Et2O (9.8 mL, 19.6 mmol) is added to a solution of 2-cyano4-methyl-2-pentenoic acid (3.0 g, 19.6 mmol) in 50 mL of THF which is cooled in an IPA/dry ice bath to −40° C. under argon. The solution is stirred for 4 hours, and the reaction is quenched by addition of 50 mL of saturated KH2PO4. The THF is evaporated, and the remaining oil is chromatographed under medium pressure over silica gel with 50% CH2Cl2/hexane. Yield=1.9 g (50%) of 2-cyano-3-isopropyl-hexanoic acid methyl ester as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06642398B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-95663f39283f40eebdf4a2bdf8748c20 |
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| 출처 메모 | uspto-grants-2003_11 |
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