Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-(3-Oxo-1-phenylbutyl)-4-phenyl-2-oxo-4-oxazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | 4-Phenyl-3-Buten-2-one | HCID 15909 | — |
| 반응물 | 4-Oxazolin-2-one, 4-phenyl- | HCID 118669 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 5-(3-Oxo-1-phenylbutyl)-4-phenyl-2-oxo-4-oxazoline | HCID 15541756 | 86.3% |
반응 단계
To a solution of 4-phenyl-2-oxo-4-oxazoline (1.61 g) and benzalacetone (1.46 g) in acetonitrile (20 ml) was added dropwise methanesulfonic acid (0.96 g). After stirring the obtained mixture at room temperature for 30 min, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with water and dried (MgSO4), and the solvent was evaporated. The residue was subjected to silica gel column chromatography and eluted with hexane-ethyl acetate (1:1). The solvent was evaporated. Crystallization from isopropyl ether gave 4-(4-phenyl-2-oxo-4-oxazolin-5-yl)-4-phenyl-2-butanone (2.65 g; yield 86.3%). Recrystallization from ethanol gave colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699995B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-547f94840dbf42e1b5c1663b995de3f7 |
| 출처 메모 | uspto-grants-2004_03 |