Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 479246생성일: 2026년 10월 26일
Allyl bromide → [Rac]-3-(3-allyl-4-hydroxy-naphthalen-1-yl)-2-ethoxy-propionic acid ethyl ester
https://huagongshe.com/reaction/479246
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Allyl bromide | HCID 7841 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | [Rac]-2-ethoxy-3-(4-hydroxy-naphthalen-1-yl)-propionic acid ethyl ester | HCID 68616503 | — |
| 반응물 | [Rac]-3-(4-allyloxy-naphthalen-1-yl)-2-ethoxy-propionic acid ethyl ester | HCID 69557260 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | [Rac]-3-(3-allyl-4-hydroxy-naphthalen-1-yl)-2-ethoxy-propionic acid ethyl ester | HCID 69558109 | 94% |
반응 단계
0.87 g (2.65 mmol) [rac]-3-(4-allyloxy-naphthalen-1-yl)-2-ethoxy-propionic acid ethyl ester [prepared from [rac]-2-ethoxy-3-(4-hydroxy-naphthalen-1-yl)-propionic acid ethyl ester (example 150 a] and allylbromide, potassium carbonate in acetone at 60° C.] was stirred for 2 hours at 160° C. without any solvent. The dark residue was purified by flash chromatography (silica gel, hexane/AcOEt=4:1) to yield 0.82 g (94%) of [rac]-3-(3-allyl-4-hydroxy-naphthalen-1-yl)-2-ethoxy-propionic acid ethyl ester as yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06642389B2 |
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| 출처 데이터셋 | uspto-grants-2003_11 |
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| ORD ID | ord-5fdaa05bc7494ac5a2f0226384b2d8b5 |
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| 출처 메모 | uspto-grants-2003_11 |
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