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Water → HCID 44375456, 화합물

HRID 479313
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HRID 479313 반응식
Cl[CH2:2][C@@H:3]([CH2:5][CH2:6][CH2:7][C@H:8]([C@@H:10]1[C@:27]2([CH3:28])[C:13]([C:14]3[CH2:15][CH2:16][C@@H:17]4[C@:22]([C:24]=3[CH2:25][CH2:26]2)([CH3:23])[CH2:21][CH2:20][C@H:19]([OH:29])[C:18]4([CH3:31])[CH3:30])=[CH:12][CH2:11]1)[CH3:9])[CH3:4].[I-:32].[Na+].O>CC(C)=O>[I:32][CH2:2][C@@H:3]([CH2:5][CH2:6][CH2:7][C@H:8]([C@@H:10]1[C@:27]2([CH3:28])[C:13]([C:14]3[CH2:15][CH2:16][C@@H:17]4[C@:22]([C:24]=3[CH2:25][CH2:26]2)([CH3:23])[CH2:21][CH2:20][C@H:19]([OH:29])[C:18]4([CH3:31])[CH3:30])=[CH:12][CH2:11]1)[CH3:9])[CH3:4]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 5238Sodium IodideHCID 44375477HCID 44375477, 화합물

생성물 1

HCID 44375456HCID 44375456, 화합물수율 68.7%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
55 °C

실험 절차

A mixture of (25R)-26-chloro-4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol (50 mg, 0.1 mmol) and sodium iodide (0.8 g) in acetone (3 mL) were heated at 55° C. in a sealed reaction vessel for 3 days. Addition of water, extraction with diethyl ether and concentration under reduced pressure gave a residue which was crystallised 3 times from hexane to give the title compound (37 mg).

후처리

  1. concentrationwith diethyl ether and concentration under reduced pressure
  2. customgave a residue which
  3. customwas crystallised 3 times from hexane

출처 및 근거

ORD 기록
ord-f340476261cd4e1abd9a1a646e4b5678
출처 데이터셋
uspto-grants-2003_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06645953B2

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