2-Bromo-4'-(trifluoromethyl)acetophenone → 2-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-one

HRID 47932

반응식

HRID 47932 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:16].[Na+]>CO>[OH:16][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 3219792-Bromo-4'-(trifluoromethyl)acetophenoneHCID 2723810Sodium Formate

생성물 1

HCID 112871692-Hydroxy-1-[4-(trifluoromethyl)phenyl]ethan-1-one수율 80.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-bromo-4′-trifluoromethylacetophenone (40.0 g), sodium formate (40.0 g) and methanol (200 mL) was heated under reflux and stirred for 6 h. The reaction mixture was concentrated and poured into water (500 mL). The precipitated solid was collected by filtration, washed with water and air-dried to give the title compound as crystals (24.5 g, 80%). melting point: 112-114° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated
  4. additionpoured into water (500 mL)
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water
  7. customair-dried

출처 및 근거

ORD 기록
ord-4e10606f65fc4c4ab3290ea0ed22b311
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699995B1

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