Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 47933생성일: 2026년 10월 24일
Potassium Carbonate → Methyl 2-(2-methyl-1-imidazolyl)-4-(4-trifluoromethylphenyl)-5-oxazolepropionate
https://huagongshe.com/ko/reaction/47933
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Methylimidazole | HCID 12749 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | Methyl 2-chloro-4-(4-trifluoromethylphenyl)-5-oxazolepropionate | HCID 23431805 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 2-(2-methyl-1-imidazolyl)-4-(4-trifluoromethylphenyl)-5-oxazolepropionate | HCID 23431813 | — |
반응 단계
A mixture of methyl 2-chloro-4-(4-trifluoromethylphenyl)-5-oxazolepropionate (1.33 g), 2-methylimidazole (1.33 g), potassium carbonate (2.00 g) and N-methylpyrrolidone (10 mL) was stirred at 110° C. for 2 h. The reaction mixture was poured into iced water (100 mL), and the precipitated crystals were collected by filtration, washed with water and air-dried to give the title compound as crystals. Recrystallization from ethyl acetate-hexane gave pale-yellow prism crystals (1.07 g, 71%). melting point: 94-95° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06699995B1 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-4363cac63541420d80e534fe117fab2b |
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| 출처 메모 | uspto-grants-2004_03 |
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