Potassium cyanate → 4-methyl-N-(2,2,2-trichloro-1-isocyanatoethyl)benzamide

HRID 479496노트

반응식

HRID 479496 반응식
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9](Cl)[C:10]([Cl:13])([Cl:12])[Cl:11])=[O:7])=[CH:4][CH:3]=1.[O-:17][C:18]#[N:19].[K+]>CC(C)=O>[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]([N:19]=[C:18]=[O:17])[C:10]([Cl:13])([Cl:12])[Cl:11])=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 11378442Potassium cyanateHCID 123415764-Methyl-N-(1,2,2,2-tetrachloroethyl)benzamide

생성물 1

HCID 187707404-methyl-N-(2,2,2-trichloro-1-isocyanatoethyl)benzamide수율 60.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A stirred solution of Example 37D (1.00 g, 3.32.00 mmol) in acetone (20 mL) at ambient temperature was treated with potassium cyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 50% ethyl acetate/hexanes) to provide 620 mg of the desired product as an off-white solid.

후처리

  1. concentrationconcentrated
  2. customthe crude residue was purified by flash chromatography (elution with 50% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-67496c04989840a9921184ec86f9958e
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06645968B2

반응 노트

불러오는 중…