p-Toluenesulfonic acid → n-[1-(1h-1,2,3Benzotriazol-1-yl)-2,2-dimethylpropyl]-4-chloro-2-fluorobenzamide

반응식

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[C:4]([F:11])[CH:3]=1.[CH3:12][C:13]([CH:16]=O)([CH3:15])[CH3:14].[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH:16]([NH:8][C:6](=[O:7])[C:5]2[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][C:4]=2[F:11])[C:13]([CH3:14])([CH3:15])[CH3:12])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

참가 물질

반응물 4

HCID 6101p-Toluenesulfonic acid

HCID 12417Pivalaldehyde

HCID 37218494-Chloro-2-fluorobenzamide

HCID 178418385HCID 178418385, 화합물

생성물 1

HCID 18770717n-[1-(1h-1,2,3Benzotriazol-1-yl)-2,2-dimethylpropyl]-4-chloro-2-fluorobenzamide

실험 절차

4-Chloro-2-fluorobenzamide, pivaldehyde, benzotriazole and p-toluenesulfonic acid were processed as described in Example 53A to provide the desired product.

출처 및 근거

ORD 기록: ord-18edd09d18bc4420af66589d06713f13
출처 데이터셋: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06645968B2

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