p-Toluenesulfonic acid → n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamide

반응식

[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([NH2:7])=[O:6].[CH3:12][C:13]([CH:16]=O)([CH3:15])[CH3:14].[NH:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:18]1([CH:16]([NH:7][C:5](=[O:6])[C:4]2[CH:3]=[C:2]([F:1])[CH:10]=[C:9]([F:11])[CH:8]=2)[C:13]([CH3:14])([CH3:15])[CH3:12])[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[N:19]1

참가 물질

반응물 4

HCID 6101p-Toluenesulfonic acid

HCID 12417Pivalaldehyde

HCID 27369103,5-Difluorobenzamide

HCID 178418385HCID 178418385, 화합물

생성물 1

HCID 18770765n-(1-(1h-1,2,3-Benzotriazol-1-yl)-2,2-dimethylpropyl)-3,5-difluorobenzamide

실험 절차

3,5-Difluorobenzamide, pivaldehyde, benzotriazole and p-toluenesulfonic acid were processed as described in Example 53A to provide the desired product.

출처 및 근거

ORD 기록: ord-e0d2b190b10f48168d729451c0809585
출처 데이터셋: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06645968B2

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