Ethanol → Ethyl 6-Aminonicotinate

HRID 479733노트

반응식

HRID 479733 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[CH2:11](O)[CH3:12]>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:11][CH3:12])=[O:7])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 702EthanolHCID 184966-Aminonicotinic acid

생성물 1

HCID 235927Ethyl 6-Aminonicotinate

실험 절차

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine and concentrated to afford 1.37 g of a white solid, m/e=166(M+H).

후처리

  1. customwas bubbled in dry hydrochloric acid at 0° C.
  2. temperaturethe solution was refluxed until all the solids
  3. dissolutiondissolved
  4. customThe solvents were removed under reduced pressure
  5. dissolutionthe residue dissolved in ethyl acetate
  6. washwashed with saturated sodium bicarbonate, brine
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-16a0a4e9bd2244cdb60a968f4ae8997f
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06646010B2

반응 노트

불러오는 중…