Phosphorus pentachloride → (4-Fluoro-3-phenoxyphenyl)methanesulfonyl chloride

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][S:9]([O-])(=[O:11])=[O:10])=[CH:4][C:3]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[Na+].P(Cl)(Cl)(Cl)(Cl)[Cl:22]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][S:9]([Cl:22])(=[O:11])=[O:10])=[CH:4][C:3]=1[O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 24819Phosphorus pentachloride

HCID 86757418Sodium (4-fluoro-3-phenoxyphenyl)methanesulfonate

생성물 1

HCID 18000351(4-Fluoro-3-phenoxyphenyl)methanesulfonyl chloride

실험 절차

The sodium sulfonate obtained in step 1 is mixed with phosphorous pentachloride at room temperature for two days. An ice-water mixture is added and the aqueous solution is extracted with methylene chloride. The organic extract is washed with water, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain (4-fluoro-3-phenoxyphenyl)methanesulfonyl chloride as a syrup (2.05 g).

후처리

extractionthe aqueous solution is extracted with methylene chloride
extractionThe organic extract
washis washed with water
dry with materialdried over anhydrous sodium sulfate
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-06dc0694242f41569ec45c17784ef03d
출처 데이터셋: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06646166B1

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