1,4-Dioxa-8-azaspiro(4.5)decane → 8-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane

HRID 480

반응식

HRID 480 반응식
C1CC2(CCN1)OCCO2.COc1cccc(Br)n1>CC(=O)O.CC(=O)O.CC(C)(C)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.[Na+].[Pd]>COc1cccc(N2CCC3(CC2)OCCO3)n1

참가 물질

6

반응물 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 2568102-Bromo-6-methoxypyridine

생성물 1

HCID 815811468-(6-Methoxy-2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane수율 69.11%

시약·촉매·용매 3

HCID 23676156Sodium t-butoxide시약HCID 4144353Palladium (II) acetate촉매HCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl촉매

실험 절차

The same procedure as EN03653-93-01.

출처 및 근거

ORD 기록
ord-74d98b785957480d946a0d3ab89bccf5
출처 데이터셋
750 AstraZeneca ELN dataset
원본 링크
출처 보기

연결된 노트

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