Acetone → 4-Amino-2-chlorobenzoic acid

HRID 48006

반응식

HRID 48006 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H].CC(C)=O>C(O)C.[C].[Pd]>[NH2:11][C:9]1[CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([Cl:1])[CH:10]=1

참가 물질

6

반응물 3

HCID 180AcetoneHCID 74482-Chloro-4-nitrobenzoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 171544-Amino-2-chlorobenzoic acid

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

In ethanol (250 mL) was dissolved 100 g (F.W. 201.57, 496 mmol) of 2-chloro-4-nitrobenzoic acid (1) and after replacing with argon, a 10% palladium carbon catalyst (4.0+1.5 g) was added thereto. After replacing with hydrogen, the mixture was stirred at room temperature for 72 hours. The formed crystal was dissolved with acetone and filtered to remove the catalyst. The solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2).

후처리

  1. filtrationfiltered
  2. customto remove the catalyst
  3. distillationThe solvent was distilled under reduced pressure to quantitatively obtain 88 g of the target 4-amino-2-chlorobenzoic acid (2)

출처 및 근거

ORD 기록
ord-1a0fb14af5eb4c08bc790f0d9076e4d8
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06700013B2

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