4-Chloroaniline → ethyl acetoacetate, sodium salt

HRID 480068

반응식

HRID 480068 반응식
ClC1C=CC(N)=CC=1.C([CH:11]([C:17]([CH3:19])=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13])C.Cl.C([OH:23])C>>[O:23]=[C:11]([CH2:17][CH3:19])[C:12]([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

4

반응물 3

HCID 78124-ChloroanilineHCID 79065Butanoic acid, 2-ethyl-3-oxo-, ethyl esterHCID 21887872Ethanol hydrochloride

생성물 1

HCID 85195ethyl acetoacetate, sodium salt

실험 절차

The p-chlorophenylhydrazone of ethyl 2-oxobutanoate was prepared by adaptation of the Japp-Klingemann reaction as described by Lions and Hughes (J. Proc. Roy. Soc. N.S. Wales 1939, 71: 445) to p-chloroaniline and ethyl 2-ethylacetoacetate. This phenylhydrazone was treated with HCl-ethanol according to the procedure of Lions and Hughes (J. Proc. Roy. Soc. N.S. Wales 1939, 71: 445) as applied therein to the corresponding bromophenylhydrazone. The title substance was collected by filtration as an orange solid after suspending the concentrated residue in water.

후처리

  1. filtrationThe title substance was collected by filtration as an orange solid

출처 및 근거

ORD 기록
ord-5293d7755e5f4c0ca75af02f1701131b
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649634B2

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