Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Ethyl 2-(4-(cyclopropanecarbonyl)phenyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4-(Cyclopropylcarbonyl)benzeneacetic acid | HCID 193731 | — |
| 촉매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | Ethyl 2-(4-(cyclopropanecarbonyl)phenyl)acetate | HCID 11218514 | 88% |
반응 단계
Dissolve 4-(cyclopropylcarbonyl)benzeneacetic acid in ethanol (150 mL) containing concentrated sulfuric acid (10 drops). Stir 24 hours. Add triethylamine (2 mL) and concentrate the solution. Dissolve the residue in water/ethyl acetate. Wash the organic phase with saturated sodium hydrogen carbonate solution, dry over anhydrous magnesium sulfate and concentrate. Purify by silica gel chromatography (400 mL silica gel, 20% ethyl acetate/heptane as eluent) to give the title compound (7.0 g, 88%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06700012B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-f0360d79b5a64416b111ea0c372ef3f1 |
| 출처 메모 | uspto-grants-2004_03 |