Tetrabutylammonium Fluoride → 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthol

HRID 480444

반응식

HRID 480444 반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[CH:33]=[C:32]([C:37]([C:42]1[N:43]=[CH:44][N:45]([C:47]([C:60]3[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=3)([C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH:46]=1)([OH:41])[CH:38]([CH3:40])[CH3:39])[CH:31]=[CH:30]2)(C(C)(C)C)(C)C>C1COCC1>[OH:41][C:37]([C:32]1[CH:33]=[C:34]2[C:29](=[CH:30][CH:31]=1)[CH:28]=[C:27]([OH:26])[CH:36]=[CH:35]2)([C:42]1[N:43]=[CH:44][N:45]([C:47]([C:54]2[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=2)([C:60]2[CH:65]=[CH:64][CH:63]=[CH:62][CH:61]=2)[C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH:46]=1)[CH:38]([CH3:39])[CH3:40]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 220184421-(6-tert-butyldimethylsilyloxy-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol

생성물 1

HCID 220183856-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthol수율 98.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of tetrabutylammonium fluoride in THF (1 M, 100 mL) was added to a solution of 1-(6-tert-butyldimethylsilyloxy-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (35.0 g) in THF (100 ml) at 0° C. and the mixture was stirred at room temperature for 1 h. The solvent was evaporated, and water was added to the residue. The precipitate was filtered, washed with diethyl ether and water to give the titled compound (28.3 g) as a colorless powder.

후처리

  1. customThe solvent was evaporated
  2. additionwater was added to the residue
  3. filtrationThe precipitate was filtered
  4. washwashed with diethyl ether and water

출처 및 근거

ORD 기록
ord-90495403c86a47aca0b44d4773644ca8
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649643B1

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