Ethanol → [1,1'-Biphenyl]-4-amine, 3-nitro-

HRID 480509

반응식

HRID 480509 반응식
[OH-].[K+].[N+:3]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=[CH:10][C:11]=1[NH:12]C(=O)C)([O-:5])=[O:4].C(O)C>O>[N+:3]([C:6]1[CH:7]=[C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:9]=[CH:10][C:11]=1[NH2:12])([O-:5])=[O:4]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 79364Acetamide, N-(3-nitro(1,1'-biphenyl)-4-yl)-2회

생성물 1

HCID 77705[1,1'-Biphenyl]-4-amine, 3-nitro-수율 71.8%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of potassium hydroxide (2.5 g), 3-nitro-4-acetamido-1,1′-biphenyl (23.5 g), prepared in (A) above, water (6 mL) and ethanol (12 mL) is heated at reflux for one hour. The reaction mixture is cooled to room temperature and then poured into 300 mL of a mixture of water and ice. The solid is collected by filtration and the crude product is recrystallized from methanol (800 mL) to give 14.1 g of the title compound as an orange solid melting at 170-172° C.

후처리

  1. temperatureis heated
  2. temperatureat reflux for one hour
  3. filtrationThe solid is collected by filtration
  4. customthe crude product is recrystallized from methanol (800 mL)

출처 및 근거

ORD 기록
ord-1530f57a55bb4b08a15376989465a1e8
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649770B1

연결된 노트

불러오는 중…