3H-Indole, 2,3,3-trimethyl- → n-(5-Carboxypentyl)-2,3,3-trimethylindolinium bromide

반응식

[CH3:1][C:2]1[C:10]([CH3:12])([CH3:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>>[Br-:13].[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH+:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([CH3:12])([CH3:11])[CH:2]1[CH3:1])([OH:21])=[O:20]

참가 물질

반응물 2

HCID 154273H-Indole, 2,3,3-trimethyl-

HCID 202106-Bromohexanoic acid

생성물 1

HCID 18764706n-(5-Carboxypentyl)-2,3,3-trimethylindolinium bromide

실험 절차

N-(5-carboxypentyl)-2,3,3-trimethylindolinium bromide was prepared by the process set forth in Example IA with 2,3,3-trimethylindolenine and 6-bromohexanoic acid to produce 2.43 grams (71.2 percent yield) of yellow crystals. 1H and 13C NMR spectra indicated the following:

출처 및 근거

ORD 기록: ord-af12284382fa4823b11ccf8d250460d4
출처 데이터셋: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06652959B2

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