Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 480608생성일: 2026년 10월 24일
Sodium Iodide → [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine
https://huagongshe.com/ko/reaction/480608
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| 반응물 | 4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine | HCID 13413724 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine | HCID 178419077 | — |
반응 단계
To a solution of above-prepared 4,6-dichloro-2-(4-methoxy-benzylsulfanyl)-pyrimidine (915 mg, 3.04 mmol) and 3-amino-5-methylpyrazole (310 mg, 3.19 mmol) in BuOH (20 mL) is added diisopropylethylamine (0.56 mL, 3.19 mmol) followed by sodium iodide (455 mg, 3.04 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06653300B2 |
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| 출처 데이터셋 | uspto-grants-2003_11 |
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| ORD ID | ord-a963d47eb7884ecbb6832fc6d11cb7fa |
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| 출처 메모 | uspto-grants-2003_11 |
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