참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 4,6-Dichloro-2-(methylthio)pyrimidine | HCID 80531 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | HCID 178418729 | HCID 178418729 | — |
반응 단계
To a solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine (5 g, 25.6 mmol) and 3-amino-5-methylpyrazole 2.61 g, 26.9 mmol) in BuOH (60 mL) is added diisopropylethylamine (4.69 mL, 26.9 mmol) followed by sodium iodide (3.84 g, 25.6 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is then removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gradient) to give [6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06653301B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-36a0652be649493ba3eb99410249ed66 |
|---|
| 출처 메모 | uspto-grants-2003_11 |
|---|
