참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Bromoaniline | HCID 11562 | — |
| 반응물 | 2-(Trifluoromethyl)oxirane | HCID 520769 | — |
| 생성물 | 3-[(3-Bromophenyl)amino]-1,1,1-trifluoro2-propanol | HCID 23506102 | 84% |
반응 단계
Ex-633A) 3-Bromoaniline (2.15 g, 12.5 mmol) and 1,1,1-trifluoro-2,3-epoxypropane (1.0 g, 8.9 mmol) were placed in a sealed vial, heated to 70° C. and stirred for 1 h under an atmosphere of nitrogen. The crude product was purified by flash column chromatography on silica gel eluting with CH2CH2:hexane (2:1) to give 2.11 g (84%) of the desired 3-[(3-bromophenyl)amino]-1,1,1-trifluoro-2-propanol product as a light amber oil, 98% pure by HPLC analysis. MS m/z=284/286 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06699898B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-95a93c4cf6c848f2a9926d190087c059 |
|---|
| 출처 메모 | uspto-grants-2004_03 |
|---|
