3,4,5-Trimethoxybenzoic Acid → 2-Bromo-3,4,5-trimethoxybenzoic acid

HRID 48085

반응식

HRID 48085 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9]>C(O)(=O)C>[Br:1][C:11]1[C:12]([O:16][CH3:17])=[C:13]([O:14][CH3:15])[C:5]([O:4][CH3:3])=[CH:6][C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 83573,4,5-Trimethoxybenzoic AcidHCID 24408Bromine

생성물 1

HCID 3130972-Bromo-3,4,5-trimethoxybenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of bromine (100 mmol) in 100 mL of acetic acid is added dropwise to a solution of 3,4,5-trimethoxybenzoic acid (100 mmol) in 100 mL of acetic acid cooled by an ice water bath. After the red color of the resulting mixture is discharged, the mixture is poured onto 500 g of crushed ice. The resulting solid is collected by filtration, dried over P2O5 in vacuo, and recrystallized from Et2O to give the product as a pale yellow solid.

후처리

  1. temperaturecooled by an ice water bath
  2. filtrationThe resulting solid is collected by filtration
  3. dry with materialdried over P2O5 in vacuo
  4. customrecrystallized from Et2O

출처 및 근거

ORD 기록
ord-b83e621f8de54011ba0a2acf013a775e
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06702705B1

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