참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 3-[(Tert-butyldimethylsilyl)oxy]propan-1-ol | HCID 4077791 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-((Tert-butyldimethylsilyl)oxy)propanal | HCID 3662392 | — |
반응 단계
DMSO (24 mmol) is added to oxalyl chloride (11 mmol) in 40 mL of CH2Cl2 cooled to −78° C. After 15 minutes, alcohol 46 (10 mmol) is added. After an additional 15 minutes, triethylamine (50 mmol) is added. The mixture is allowed to warm to 0° C. and then poured into 0.1 M HCl (100 mL). The phases are separated, and the aqueous phase is extracted with ethyl acetate (2×100 mL). The organic phases are washed with water (100 mL), dried over anhydrous MgSO4, and concentrated in vacuo. The mixture is purified by flash chromatography to give the product as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06702705B1 |
|---|
| 출처 데이터셋 | uspto-grants-2004_03 |
|---|
| ORD ID | ord-5c15f2fb99da45d49beebf1bfbf5498f |
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| 출처 메모 | uspto-grants-2004_03 |
|---|
