Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → tert-Butyl 2-bromo-2-methylpropionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Isobutylene | HCID 8255 | — |
| 반응물 | 2-Bromo-2-methylpropanoic acid | HCID 74924 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-Butyl 2-bromo-2-methylpropionate | HCID 90290 | — |
반응 단계
Isobutene is condensed into a solution of 2-bromo-2-methylpropanoic acid (10 mmol) and trifluoroacetic acid (1 mmol) in 100 mL of CH2Cl2 until the starting material is consumed, as observed by TLC. The volatile components are evaporated in vacuo, and the residue is filtered through a pad of neutral alumina using 50% ether/hexane. The filtrate is concentrated in vacuo and used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06702705B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-5762bebda38142938f4f6eeb9c672c4b |
| 출처 메모 | uspto-grants-2004_03 |