참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Salbutamol Sulfate | HCID 9884233 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Salbutamol | HCID 2083 | — |
반응 단계
In an alternative embodiment, the inhalation solution of the present invention may be prepared as follows: (i) fitting a high density polyethylene (HDPE) or stainless steel formulation tank with a bottom drain and peristaltic recirculation system (for HDPE) or tri-blender (for stainless steel) for mixing; (ii) filling the tank with approximately 90% of the required amount of Purified Water USP at a temperature of between 18° C. to 25° C.; while mixing, (iii) adding sulfuric acid, Sodium Chloride USP, and at least a therapeutically effective pediatric amount of Albuterol Sulfate USP to the tank; (iv) continue mixing until all chemical components are dissolved; (v) adding Purified Water USP to adjust the final volume, if necessary, thus producing an albuterol mixture.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06702997B2 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-5e22ad9c5cce42a49be1bce2ca1f9a58 |
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| 출처 메모 | uspto-grants-2004_03 |
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