Potassium Dichromate → 3'-METHOXY-3-PHENYLPROPIOPHENONE

HRID 481162노트

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HRID 481162 반응식
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1>O.S(=O)(=O)(O)O.CCOCC>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:20](=[O:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1

참가 물질

6

반응물 2

HCID 24502Potassium DichromateHCID 15524231HCID 15524231, 화합물

생성물 1

HCID 112071953'-METHOXY-3-PHENYLPROPIOPHENONE수율 83.2%

시약·촉매·용매 3

HCID 962Water용매HCID 1118Sulfuric Acid용매HCID 3283Diethyl Ether용매

반응 조건

온도
20 °C

실험 절차

14.9 g (0.05 mole) of potassium dichromate in a mixture of 50 ml of water and 10 ml of concentrated sulfuric acid were added to a solution of 34 g (0.14 mole) of 1-(3-methoxyphenyl)-3-phenylpropan-1-ol in 500 ml of ether while cooling with ice and stirred overnight at 20° C. The aqueous, green phase was separated and extracted twice with 100 ml of ether each time. The combined ether extracts were dried over sodium sulfate and the solvent was then removed in vacuo. 28.0 g (83%) of the compound 1-(methoxyphenyl)-3-phenylpropan-1-one were obtained as a yellow oil, which was reacted further without prior purification.

후처리

  1. temperaturewhile cooling with ice
  2. customThe aqueous, green phase was separated
  3. extractionextracted twice with 100 ml of ether each time
  4. dry with materialThe combined ether extracts were dried over sodium sulfate
  5. customthe solvent was then removed in vacuo

출처 및 근거

ORD 기록
ord-592d635826f04e7fb005ac5fb930fe88
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653508B2

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