3-Methoxybenzaldehyde → (2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride

HRID 481164

반응식

HRID 481164 반응식
[Cl:1]C1C=CC(Cl)=CC=1C=O.COC1C=C(C=CC=1)C=O.[ClH:21].[CH2:22]([CH:29]([CH2:40][N:41]([CH3:43])[CH3:42])[C:30]([C:32]1[CH:37]=[CH:36][C:35](Cl)=[CH:34][C:33]=1[Cl:39])=[O:31])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[ClH:1].[CH2:22]([CH:29]([CH2:40][N:41]([CH3:43])[CH3:42])[C:30]([C:32]1[CH:37]=[C:36]([Cl:21])[CH:35]=[CH:34][C:33]=1[Cl:39])=[O:31])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

4

반응물 3

HCID 115693-MethoxybenzaldehydeHCID 807022,5-DichlorobenzaldehydeHCID 18767270(2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride

생성물 1

HCID 18767286(2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride

실험 절차

The synthesis was carried out according to the procedure of Example 1, except that 5.0 g (0.028 mole) of 2,5-dichlorobenzaldehyde were used instead of 3-methoxybenzaldehyde. The reaction steps involving Grignard reaction, oxidation and Mannich reaction led to a total yield of 1.4 g (14%) of (2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride with a melting point of 140° C.

후처리

  1. customThe reaction steps
  2. customGrignard reaction, oxidation and Mannich reaction

출처 및 근거

ORD 기록
ord-207ef4f9f5a64ae1989bb39099596136
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653508B2

연결된 노트

불러오는 중…