Resazurin → HCID 178515439, 화합물

HRID 481182

반응식

HRID 481182 반응식
[CH:1]1[C:6]([OH:7])=[CH:5][C:4]2[O:8][C:9]3[C:15](=[N+:16]([O-])[C:3]=2[CH:2]=1)[CH:14]=[CH:13][C:11](=[O:12])[CH:10]=3>O.[NH4+].[OH-].[Zn]>[OH:7][C:6]1[CH:5]=[C:4]2[C:3](=[CH:2][CH:1]=1)[N:16]=[C:15]1[C:9](=[CH:10][C:11](=[O:12])[C:13]([CH2:4][CH2:5][CH2:6][OH:7])=[CH:14]1)[O:8]2

참가 물질

5

반응물 1

HCID 11077Resazurin

생성물 1

HCID 178515439HCID 178515439, 화합물

시약·촉매·용매 3

HCID 23994Zinc촉매HCID 962Water용매HCID 14923Ammonium Hydroxide용매

실험 절차

The crude resazurin compound was suspended in a mixture of 200 mL of water and 50 mL of conc. NH4OH. Zinc dust (2.0 g) was added and the suspension was stirred for 20 min. The resultant purple mixture was filtered, the filtrate was vigorously stirred on air to oxidize the leuco resorufin, the product of partial over reduction. The reaction was acidified with acetic acid, the brown solid formed was collected by filtration washed with water and dried. The yield was 2.1 g. The material contained ˜50% of 2,3,4-trihydro-2H-pyrano[3,2-b]phenoxazin-9-one, product of intramolecular cyclization which had been carried over from the first step. The rest of the material was the desired title compound 35.

후처리

  1. filtrationThe resultant purple mixture was filtered
  2. stirringthe filtrate was vigorously stirred on air
  3. customthe brown solid formed
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-abc79c220d6342b8b8fbf72480c79147
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653473B2

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