Ethanethiol → 2-Bromo-5,6-dihydro-5,5-dimethyl8-(ethylthio)-naphthalene

HRID 481207

반응식

HRID 481207 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])([CH3:13])[CH2:7][CH2:8][C:9]2=O)=[CH:4][CH:3]=1.[CH2:15]([SH:17])[CH3:16].C(N(CC)CC)C>O1CCCC1.O.[Ti](Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]([CH3:14])([CH3:13])[CH2:7][CH:8]=[C:9]([S:17][CH2:15][CH3:16])[C:10]=2[CH:11]=1

참가 물질

7

반응물 3

HCID 6343EthanethiolHCID 8471TriethylamineHCID 107533577-Bromo-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-one2회

생성물 1

HCID 225715212-Bromo-5,6-dihydro-5,5-dimethyl8-(ethylthio)-naphthalene

시약·촉매·용매 3

HCID 24193Titanium Tetrachloride촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 1.03 g (4.1 mmol) of 7-bromo-3,4-dihydro-4,4-dimethylnaphthalen-1(2H)-one (Compound G) in 30.0 mL of tetrahydrofuran, was added dropwise 0.49 g (0.85 mL, 7.8 mmol) of titaniumtetrachloride and the resulting solution stirred for 10 min. A solution of 35 mg (0.50 mL, 6.7 mmol) of ethanethiol and 0.54 g (0.75 mL, 5.4 mmol) of triethylamine in 10.0 mL of tetrahydrofuran was added and the reaction stirred at room temperature for 13 h. The mixture was diluted with water and extracted with ether (2×). The organic phase was washed with brine, dried over Na2SO4 and then concentrated in vacuo. Purification by flash chromatography (silica, 100% hexane) gave the title compound as an oil.

후처리

  1. stirringthe reaction stirred at room temperature for 13 h
  2. extractionextracted with ether (2×)
  3. washThe organic phase was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo
  6. customPurification by flash chromatography (silica, 100% hexane)

출처 및 근거

ORD 기록
ord-79cc2caddbbb417b929e405bbe48a884
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653483B1

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