Potassium Hydroxide → 2',3'-Difluoro-4'-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid

HRID 48122

반응식

HRID 48122 반응식
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([F:35])([F:34])[C:24]([F:33])([F:32])[C:25]([F:31])([F:30])[C:26]([F:29])([F:28])[F:27])=[C:14]([F:36])[C:13]=2[F:37])=[CH:8][CH:7]=1)=[O:5])C.[OH-].[K+]>O.C(O)C>[F:37][C:13]1[C:14]([F:36])=[C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([F:34])([F:35])[C:24]([F:32])([F:33])[C:25]([F:30])([F:31])[C:26]([F:29])([F:27])[F:28])[CH:16]=[CH:17][C:12]=1[C:9]1[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 867593712',3'-Difluoro-4'-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic Acid Ethyl Ester

생성물 1

HCID 220162542',3'-Difluoro-4'-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

A solution of 2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid ethyl ester (13A) (1 equi.) and potassium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h., cooled to room temperature, quenched with hydrochloric acid (5%). The resulting white solid was filtered, washed with water, and dried under vacuum to give 2′,3′-difluoro-4′-(5,5,6,6,7,7,8,8,8-nonafluoro-octyloxy)-biphenyl-4-carboxylic acid (14 A) as a white solid (80%).

후처리

  1. customquenched with hydrochloric acid (5%)
  2. filtrationThe resulting white solid was filtered
  3. washwashed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-fe25aff560b64d75b3eb96ca16a2e4bd
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703082B1

연결된 노트

불러오는 중…