Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,4-dihydro-2H-pyran → 2-[(10-Bromodecyl)oxy]tetrahydro-2H-pyran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 반응물 | 1-Decanol, 10-bromo- | HCID 104507 | — |
| 촉매 | Pyridine | HCID 1049 | — |
| 촉매 | Silanol, trimethyl-, 1,1'-sulfate | HCID 87573 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[(10-Bromodecyl)oxy]tetrahydro-2H-pyran | HCID 103543 | 42.8% |
반응 단계
A mixture of 100 g 1-bromodecan-10-ol, 2.1 g bis(trimethylsilyl)sulphate, 43 g 3,4-dihydro-2H-pyran and 500 ml dichloromethane is stirred for 6 hours at room temperature. Several drops of pyridine are added and the reaction mixture evaporated down. The residue is purified by column chromatography on silica gel using hexane/ethyl acetate (1/1 v/v) as eluent to yield 58 g of 1-bromo-10-[tetrahydropyranyloxy]decane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06653499B1 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-270d3152095d4875925be10b4e5aff8a |
| 출처 메모 | uspto-grants-2003_11 |