Lipoamide → Diglycerol 1,2-distearate

HRID 481270

반응식

HRID 481270 반응식
C1C(CCCCC(N)=O)SSC1.C(O)C(O)C[O:16][CH2:17][CH:18]([OH:21])[CH2:19][OH:20].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>OCC(CO)O>[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[C:24]([OH:43])(=[O:42])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21].[OH:16][CH2:17][CH:18]([CH2:19][OH:20])[OH:21]

참가 물질

5

반응물 3

HCID 863LipoamideHCID 5281Stearic AcidHCID 42953Diglycerin

생성물 1

HCID 131720779Diglycerol 1,2-distearate수율 5%

시약·촉매·용매 1

HCID 753Glycerol용매

반응 조건

온도
70 °C

실험 절차

heating to 70°C. Thereto were added 10 parts by weight of an immobilized lipase preparation (trade name: Lipozyme, IM20, mfd. by NOVO) composed of a lipase originating from Mucor miehei immobilized on an anion exchange resin and 29 parts by weight of linear diglycerol. Then the stearic acid was reacted with the linear glycerol under reduced pressure (2 torr) at 70° C. for 4 hours. The reaction product was filtered to eliminate the immobilized enzyme. The obtained filtrate was put in a continuous thin film distilling apparatus and distillation was carried out to eliminate unreacted stearic acid and diglycerol, and monoesters. The liquid thus obtained was subjected to silica gel column chromatography to eliminate triesters, thereby giving a diglycerol distearate mixture comprising diglycerol 1,6-distearate (about 50%), diglycerol 1,5-distearate (about 45%) and diglycerol 2,5-distearate (about 5%).

후처리

  1. additionThereto were added 10 parts
  2. filtrationThe reaction product was filtered
  3. distillationdistilling
  4. distillationapparatus and distillation
  5. customThe liquid thus obtained

출처 및 근거

ORD 기록
ord-a93092b2ff014c83bfa5ca7786229ba5
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789011

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