Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzhydrylpiperazine | HCID 70048 | — |
| 반응물 | Methyl 2-(4-(bromomethyl)phenyl)acetate | HCID 11770640 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate | HCID 10993378 | 90.8% |
반응 단계
A 200 ml eggplant-shaped flask was charged with 5.38 g of methyl 4-bromomethylphenylacetate, 6.06 g of 1-benzhydrylpiperazine, 6.1 ml of triethylamine, and 100 ml of dioxane and the mixture was stirred at room temperature for 5 hours. The solvent was then distilled off and the residue was extracted with ethyl acetate. The extract was washed with water, the solvent was distilled off, and the residue was recrystallized from methanol to provide 8.33 g of methyl 4-[(4-diphenylmethyl-1-piperazinyl)methyl]phenylacetate melting at 124° C.-125° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05789409 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-89b68ced720c466195934876f641ea89 |
| 출처 메모 | uspto-grants-1998_08 |