4-Toluenesulfonyl chloride → HCID 67620835, 화합물

HRID 481312노트

반응식

HRID 481312 반응식
[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[N+:13]([O-])[CH:14]=[CH:15][C:16]=1[CH3:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC(S([Cl:28])(=O)=O)=CC=1>O1CCOCC1>[ClH:28].[CH2:1]([O:8][C:9]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][C:16]=1[CH2:17][Cl:28])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 53818160HCID 53818160, 화합물

생성물 1

HCID 67620835HCID 67620835, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of the title compound of Preparation 7 (1.8 g, 7.3 mmol), p-toluenesulfonylchloride (2.0 g, 11 mmol) and dioxane (10 ml) was heated under reflux for 1.5 hours. The reaction mixutre was cooled to 0° C., diluted with water, treated with solid NaHCO3 and extracted with diethyl ether. The ether extracts were combined, dried (Na2 SO4), filtered and treated with HCl gas. The precipitate was filtered and washed with diethyl ether to afford 1.4 g of the title compound of this preparation. mp 149°-151° C. 1H NMR (CDCl3): δ 5.27 (2H, s), 5.42 (2H, s), 7.32-7.39 (5H, m), 8.35 (1H, d, J=6), 8.91 (1H, d, J=6), 9.28 (1H, s).

출처 및 근거

ORD 기록
ord-bd0ae2341e5c4d298a4fdb2a25dbb2fc
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789408

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