1-(1-Naphthyl)piperazine → 2-Chloro-1-[4-(1-naphthyl)piperazin-1-yl]ethanone

HRID 481366

반응식

HRID 481366 반응식
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[CH2:7][CH2:6]1)=[O:4].ClCC(Cl)=O.[C:23]1(N2CCNCC2)[C:32]2C(=CC=CC=2)C=C[CH:24]=1.C(=O)([O-])[O-].[Ca+2]>C(C(C)=O)C>[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[C:12]3[C:13](=[CH:24][CH:23]=[CH:32][CH:17]=3)[CH:14]=[CH:15][CH:16]=2)[CH2:7][CH2:6]1)=[O:4]

참가 물질

6

반응물 4

HCID 13421-(1-Naphthyl)piperazineHCID 6577Chloroacetyl chlorideHCID 10112Calcium CarbonateHCID 47412122-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

생성물 1

HCID 47412412-Chloro-1-[4-(1-naphthyl)piperazin-1-yl]ethanone수율 92%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Compound 49A is prepared according to the procedure described for compound 12A using the following reactants: chloroacetyl chloride (270 ml, 3.45 mmol); 1-(1-naphthyl)piperazine (610 mg, 2.88 mmol); calcium carbonate (860 mg, 8.64 mmol); methyl ethyl ketone (20 ml).

출처 및 근거

ORD 기록
ord-9322168791ba41ad9e780d551849caaa
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789412

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