2-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine → 2-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl ester

HRID 481396

반응식

HRID 481396 반응식
[CH2:1]([O:3][C:4]([C:6]1([C:15]2[S:16][C:17]([CH2:20]Cl)=[CH:18][CH:19]=2)[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])[CH3:2].[CH:22]1([C:25]2[NH:26][C:27]3[C:28]([N:35]=2)=[N:29][C:30]([CH3:34])=[CH:31][C:32]=3[CH3:33])[CH2:24][CH2:23]1>>[CH2:1]([O:3][C:4]([C:6]1([C:15]2[S:16][C:17]([CH2:20][N:35]3[C:28]4=[N:29][C:30]([CH3:34])=[CH:31][C:32]([CH3:33])=[C:27]4[N:26]=[C:25]3[CH:22]3[CH2:24][CH2:23]3)=[CH:18][CH:19]=2)[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 103134402-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridineHCID 570789242-(5-Chloromethylthiophen-2-yl)-indan-2-carboxylic acid ethyl ester2회

생성물 1

HCID 700837152-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl ester

실험 절차

The product of Example 6, Step 4, above (26), was alkylated as described in Example 1, Step 5, using 2-cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridine (13) to obtain the title compound (29).

출처 및 근거

ORD 기록
ord-7474aaa5a7444585a58bef72af5902dc
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789415

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