Ethanol → 5-methyl-3H-benzofuran-2-one

HRID 481410

반응식

HRID 481410 반응식
Cl[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1.C(O)C>C(O)C.C(OCC)(=O)C.[Pd]>[CH3:2][C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[CH2:8][C:7]=2[CH:12]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 190662885-chloromethyl-3H-benzofuran-2-one2회

생성물 1

HCID 100576465-methyl-3H-benzofuran-2-one

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

A solution of the product of Step 1, above (55) (10.89 mmol), in ethanol/ethyl acetate (23 ml/5 ml) was added to 10 ml ethanol over 10% palladium catalyst on carbon (100 mg). The mixture was hydrogenated on a Parr shaker at 45 psi for 2 hours. The reaction mixture was filtered through celite and the organics were concentrated to dryness to obtain the title compound (56).

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe organics were concentrated to dryness

출처 및 근거

ORD 기록
ord-bbbe0f91cc634aafa054f649f7c01920
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789415

연결된 노트

불러오는 중…