참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | (5-Methylbenzofuran-2-yl)acetic acid ethyl ester | HCID 70085569 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 57107164 | HCID 57107164 | — |
반응 단계
To a solution of the product of Step 3, above (57) (1.85 mmol), in 2 ml DMF was added 60% sodium hydride in oil (3.6 mmol) at ambient temperature. The reaction mixture was stirred for 15 minutes and then 1,4-dibromobutane (1.85 mmol) was added. The reaction mixture was heated to 80° C. for 2 hours, cooled to ambient temperature, diluted with EtOAc and washed with saturated sodium bicarbonate and brine. The combined organics were then dried over MgSO4, filtered and concentrated to dryness. The crude material was chromatographed on silica gel using 10% EtOAc in hexanes as the eluant to obtain the title compound (58).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05789415 |
|---|
| 출처 데이터셋 | uspto-grants-1998_08 |
|---|
| ORD ID | ord-2d6ceee18c7a4682a44f5c56f74fc782 |
|---|
| 출처 메모 | uspto-grants-1998_08 |
|---|
