Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 8-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 3-Fluorophenyl isocyanate | HCID 123064 | — |
| 반응물 | 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride | HCID 18975490 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 8-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one | HCID 19065994 | 21.5% |
반응 단계
The preparation is carried out as in Example 36 but from 1.5 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 30 ml of dimethylformamide, 0.97 g of triethylamine and 2.64 g of 3-fluorophenyl isocyanate. There is obtained 0.44 g of 8-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one in the form of a light brown solid melting above 260° C. (Analysis, % calculated C: 64.00, H: 3.76, F: 5.06, N: 18.66, O: 8.52, % found C: 64.1, H: 3.4, N: 18.6).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05789406 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-998ab15439d04bcdb15fbdc56cc3707b |
| 출처 메모 | uspto-grants-1998_08 |