Methyl 2-(4-hydroxy-3-nitrophenyl)acetate → Methyl 2-(3-amino-4-hydroxyphenyl)acetate

HRID 48148

반응식

HRID 48148 반응식
[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([N+:12]([O-])=O)[CH:6]=1>[Pd].CO>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([NH2:12])[CH:6]=1

참가 물질

4

반응물 1

HCID 1473109Methyl 2-(4-hydroxy-3-nitrophenyl)acetate

생성물 1

HCID 1475136Methyl 2-(3-amino-4-hydroxyphenyl)acetate수율 98.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Methyl(4-hydroxy-3-nitrophenyl)acetate [from step 3] (48.9 g, 0.23 mole) and 5% palladium on carbon were suspended in methanol and the resulting mixture was hydrogenated until all the starting material had been consumed. The reaction mixture was filtered to remove the catalyst and the filtercake was washed with methanol. The combined filtrate and washings were concentrated in vacuo, affording methyl(3-amino-4-hydroxyphenyl)acetate as a solid (41.0 g).

후처리

  1. customhad been consumed
  2. filtrationThe reaction mixture was filtered
  3. customto remove the catalyst
  4. washthe filtercake was washed with methanol
  5. concentrationThe combined filtrate and washings were concentrated in vacuo

출처 및 근거

ORD 기록
ord-7084f53764894ab79b3924f11ea5a968
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703347B2

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