(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine → (2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride

HRID 481487

반응식

HRID 481487 반응식
[C:1]([C:3]1([C:6]2[CH:7]=[CH:8][C:9]([O:26][CH3:27])=[C:10]([CH:25]=2)[CH2:11][NH:12][C@H:13]2[CH2:18][CH2:17][CH2:16][NH:15][C@H:14]2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:5][CH2:4]1)#[N:2].[ClH:28].CO>>[ClH:28].[ClH:28].[C:1]([C:3]1([C:6]2[CH:7]=[CH:8][C:9]([O:26][CH3:27])=[C:10]([CH:25]=2)[CH2:11][NH:12][C@H:13]2[CH2:18][CH2:17][CH2:16][NH:15][C@H:14]2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:4][CH2:5]1)#[N:2]

참가 물질

3

반응물 2

HCID 9799042(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidineHCID 21893726Hydrochloride methanol

생성물 1

HCID 9954592(2S,3S)-3-(5-(1-Cyanocyclopropyl)-2-methoxybenzyl)amino-2-phenylpiperidine dihydrochloride수율 85%

실험 절차

Compound 4 (89 mg, 0.25 mmol) was treated with hydrogen chloride-methanol (5 ml). After the solvent was evaporated in vacuo, the residue (pale yellow solid) was recrystallized from ethanol-diethyl ether to give Compound 5 (91 mg, 85%) as a white solid.

후처리

  1. customAfter the solvent was evaporated in vacuo
  2. customthe residue (pale yellow solid) was recrystallized from ethanol-diethyl ether

출처 및 근거

ORD 기록
ord-f263c02321954e629af05718b16c72d2
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789423

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