Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | (2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine | HCID 11311934 | — |
| 반응물 | 5-(1-Cyanoethyl)-2-methoxybenzaldehyde | HCID 19066487 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine | HCID 57028229 | 103.8% |
반응 단계
To a stirred and ice-cooled solution of Compound 17 (160 mg, 0.60 mmol) and Compound 14 (120 mg, 0.60 mmol) in dry CH2Cl2 (5 ml) was added NaBH(OAc)3 (430 mg, 2.0 mmol) in one portion. The mixture was stirred at room temperature for 20 hours. The mixture was poured into NaHCO3 aq., and extracted with CH2Cl2. The combined extracts were dried (Na2SO4), and concentrated in vacuo to give Compound 18 as a yellow oil (280 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05789423 |
| 출처 데이터셋 | uspto-grants-1998_08 |
| ORD ID | ord-6d9f25a64db247fdb285099b400e9bed |
| 출처 메모 | uspto-grants-1998_08 |