(2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine → (2S,3S)-3-(2-methoxy-5-(1,1-dimethyl-2-propynyl)benzyl)amino-2-phenylpiperidine

HRID 481502노트

반응식

HRID 481502 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([CH3:26])([CH3:25])[C:23]#[CH:24])[CH:19]=[CH:18][C:17]=2[O:27][CH3:28])[C@@H:9]1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=O)(C)(C)C.C(C(C1C=CC(OC)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)C)#N>>[CH3:28][O:27][C:17]1[CH:18]=[CH:19][C:20]([C:22]([CH3:26])([CH3:25])[C:23]#[CH:24])=[CH:21][C:16]=1[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

참가 물질

3

반응물 2

HCID 57058185(2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidineHCID 57107807(2S,3S)-1-tert-Butoxycarbonyl-3-(2-methoxy-5-(1,1-dimethyl-2-propynyl)benzyl)amino-2-phenylpiperidine

생성물 1

HCID 57071301(2S,3S)-3-(2-methoxy-5-(1,1-dimethyl-2-propynyl)benzyl)amino-2-phenylpiperidine

실험 절차

This compound was prepared from Compound 23 in the same manner of Compound 19.

출처 및 근거

ORD 기록
ord-376c08329dc040caa37ba44a497be290
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789423

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